156 IMPACT OF TRANSCATHETER EDGE-TO-EDGE MITRAL VALVE REPAIR ON GUIDELINE DIRECTED MEDICAL THERAPY OPTIMIZATION IN PATIENT WITH SECONDARY MITRAL REGURGITATION

Abstract Background Guideline-directed medical therapy (GDMT) optimization is mandatory before transcatheter edge-to-edge mitral valve repair (M-TEER) in patients with secondary regurgitation (SMR) and heart failure reduced ejection fraction (HFrEF). However, the effect of M-TEER on GDMT unknown. Objective To evaluate frequency prognostic implications predictors after SMR HFrEF. Methods This a retrospective analysis prospectively collected data from EuroSMR Registry. The primary events were all-cause death composite or HF hospitalization. Results Among 1641 patients, 810 had full datasets regarding included this study. occurred 307 (38%) M-TEER. Proportion receiving ACEi/ARB/ARNI, betablockers MRA was 78%, 89% 62% 84%, 91% 66% 6-month (All p<0.001). Patients lower risk (adjusted hazard ratio [HR] 0.62; 95% confidence interval [CI] 0.41-0.93; p=0.020) hospitalization HR 0.54; CI 0.38-0.76; p<0.001) compared those without. Degree MR reduction between baseline follow-up an independent predictor OR 1.71; 1.08-2.71; p=0.022). Conclusions HFrEF considerable proportion independently associated rates for mortality hospitalizations. A greater decrease increased likelihood optimization.